B cell maturation antigen

Bcma is highly expressed on plasmablasts and plasma cells. Thus, antigen induces death or unresponsiveness rather than division and differentiation.

Here, we describe the case of a patient with mm.

B cell maturation antigen. A novel biomarker to predict outcomes for multiple myeloma (mm) patients. The marketwatch news department was not involved in the creation of this content. Bcma is highly expressed on plasmablasts and plasma cells.

Here, we describe the case of a patient with mm. Thus, antigen induces death or unresponsiveness rather than division and differentiation. At the slo, b cell activation begins when the b cell binds to an antigen via its bcr.

The membrane bound bcma can be cleaved by gamma secretase, resulting in its release into the blood as sbcma. Although the events taking place. B cell maturation antigen (bcma) contributes to mm pathophysiology and is a target antigen for novel mm immunotherapy.

Sbcma is found at low levels in the serum of normal patients and elevated among patients with mm. Berdeja jg, madduri d, usmani sz, et al. B cell activation occurs in the secondary lymphoid organs (slos), such as the spleen and lymph nodes.

Immature b cell expresses migm on its cell surface. After b cells mature in the bone marrow, they migrate through the blood to slos, which receive a constant supply of antigen through circulating lymph. In parallel, the expression of soluble bcma is found to be elevated in the serum of patients with multiple myeloma (mm) and leukemia.